Paulie

Gena Rowlands

Ivy

Tony Shalhoub

Misha Vilyenkov

Cheech Marin

Ignacio

Bruce Davison

Dr. Reingold

Trini Alvarado

Adult Marie Alweather

Jay Mohr

Benny / Paulie (voice)

Buddy Hackett

Artie

Hallie Eisenberg

Marie Alweather

Matt Craven

Warren Alweather

Bill Cobbs

Virgil the Janitor

Tia Texada

Ruby / Lupe (voice)

Laura Harrington

Lila Alweather

Peter Basch

Graduate Student #1

Emily Mura-Smith

Graduate Student #2

Hal Robinson

Grandpa

Tamara Zook

Speech Therapist

Nicole Chamberlain

Shirley

Charles Parks

Gerald

Seth Mumy

Jeremy

Dig Wayne

Research Assistant #1

Michael Leydon Campbell

Research Assistant #2

Kristie Transeau

Veterinarian

Francesca Federico-O'Murchu

Molly

Jerry Winsett

Mr. Tauper

Bud Cox

Ivy's Doctor

Josh Cruze

Cantina Singer

John Roberts

Director

Mark Vargo

Second Unit Director

Jeff Rafner

First Assistant Director

Conte Mark Matal

Second Assistant Director

Elizabeth Ludwick-Bax

Script Supervisor

David Escher

Second Second Assistant Director

Kristin Killey

Second Second Assistant Director

Laurie Craig

Screenplay

Gary Levinsohn

Producer

Randi Hiller

Casting

Sarah Halley Finn

Casting

Mark Gordon

Producer