Tom Hanks
Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry
Halle Berry
Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym
Jim Broadbent
Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2
Hugo Weaving
Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie
Jim Sturgess
Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law
Bae Doona
Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute
Ben Whishaw
Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman
James D'Arcy
Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist
Zhou Xun
Talbot / Hotel Manager / Yoona-939 / Rose
Keith David
Kupaka / Joe Napier / An-kor Apis / Prescient
Susan Sarandon
Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess
Hugh Grant
Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief
David Gyasi
Autua / Lester Rey / Duophsyte
Robert Fyfe
Old Salty Dog / Mr. Meeks / Prescient 1
Martin Wuttke
Mr. Boerhaave / Guard / Leary the Healer
Brody Nicholas Lee
Javier Gomez / Jonas / Zachry's Older Nephew
Raevan Lee Hanan
Little Girl with Orison at Papa Song's / Catkin / Zachry Relative
Niall Greig Fulton
Haskell Moore's Dinner Guest / Mozza Hoggins
Louis Dempsey
Haskell Moore's Dinner Guest / Jarvis Hoggins
Martin Docherty
Haskell Moore's Dinner Guest / Eddie Hoggins
Alistair Petrie
Haskell Moore's Dinner Guest / Musician / Felix Finch / Lascivious Businessman
Zhu Zhu
Megan Sixsmith / 12th Star Clone
Sylvestra Le Touzel
Haskell Moore's Dinner Guest / Nurse Judd / Aide in Slaughtership
Dulcie Smart
Ursula's Mother / Herbalist
Jon Donahue
Moore's Accountant / Finch's Friend (uncredited)
