
Rueda was born in Madrid. Her father was a civil engineer and her mother was a ballet instructor. She is the second of three children; her siblings are named Chus and Violeta (Ms. Rodal). She and her family moved to San Juan, Alicante when she was a child because of her younger sister's asthmatic problems. She was married to Daniel Écija and had three children with him, Beliá (b.1994), María (b.1996) and Lucía (b.1998); unfortunately, their second child died of a heart disease as a baby. She is now a divorcée. When Rueda was 18 years old she moved to Madrid to study architecture, but she left the university when she met an Italian man whom she later married. Rueda returned to Madrid and worked as a salesperson and a model until she finally became a TV presenter. After that she worked as an actress on television, including the show Los Serrano, and eventually acted in films. She won a Goya Award in 2004 for her role as Julia in Mar Adentro (The Sea Inside). She received another Goya nomination for her role in the 2007 film, The Orphanage. Rueda played the lead role of the Spanish thriller Los ojos de Julia, which is produced by Guillermo Del Toro.

The Orphanage
2007 · as Laura

Mirage
2018 · as Dr. Sardón

The Body
2012 · as Mayka Villaverde

The Sea Inside
2004 · as Julia

Los Muértimer
2025

Savage Grace
2007 · as Pilar Durán

Evil Dress
2026 · as Alicia

Reversion
2025

Julia's Eyes
2010 · as Julia Levin / Sara

Querido Fotogramas
2018 · as Self

Spanish Movie
2009 · as Laura

Twin Murders: The Silence of the White City
2019 · as Alba

Free Falling
2024 · as Marisol

Orbiter 9
2017 · as Silvia

Phenomena
2023 · as Sagrario

Perfect Strangers
2017 · as Eva

Death at a Funeral
2025 · as Edurne

7th Floor
2013 · as Delia