
Sirena grew up around the U.S. and abroad her mother, Margaret Irwin-Brandon, is a harpsichordist and conductor of a Baroque Orchestra, and her father, John Irwin, was a physicist (with a significant stint as a dropped out hippie)-landed ultimately at Sanford University. After time spent at Northfield Mt. Hermon boarding school where she fell in love with theater, she attended San Francisco State University and graduated with degrees in Theater and International Relations. After a successful stint in a popular San Francisco sketch comedy group, she landed in Los Angeles where her knack for voices and accents were quickly put to use in the world of animation. This ultimately brought her to her successful career as a voice director in animation (thanks to her mentor Andrea Romano!) garnering her an Emmy nomination in 2021.

The SpongeBob SquarePants Movie
2004 · as Reporter / Driver / Ice Cream Lady (voice)

The SpongeBob Movie: Sponge Out of Water
2015 · as Computer Voice / Shocked Mob Member (voice)

Planes
2013 · as Additional Voices (voice)

SpongeBob LongPants
2016 · as Fancy Lady Fish / Kid Fish (voice)

SpongeBob Squarepants: Kreepaway Kamp
2024 · as Lady Upturn / Nurse Helga / Mo / Teen Girls (voice)

Justice League: Throne of Atlantis
2015 · as Queen Atlanna (voice)

Superman: Unbound
2013 · as Alura (voice)

Batman vs. Two-Face
2017 · as Harleen Quinzel (voice)

Batman: Return of the Caped Crusaders
2016 · as Miranda Moore (voice)

SpongeBob and Patrick's Timeline Twist-Up
2025 · as Pffht / Various Incidental Characters (voice)

Spongebob’s Runaway Roadtrip
2011 · as Margret SquarePants

SpongeBob’s Big Birthday Blowout
2019 · as SpongeBob’s Mom / Gawky Female / The Kid / Office Worker

Spongebob Squarepants: Christmas
2003 · as Woman Fish

The Trip
2002 · as Beverly

Electric Apricot
2007 · as The Photographer

Vitaminamulch: Air Spectacular
2014 · as Additional Voice

The Sky is Falling
2001 · as Gabby

Holly Hobbie and Friends: Christmas Wishes
2006 · as Mrs. Palmer (voice)